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Businesses gather in Barcelona to discuss boost for rural economy. Follow Us. Tweets by Incredibforest. SOX11 as a minimal residual disease marker for Mantle cell lymphoma. Somatic hypermutation and V H gene usage in mantle cell lymphoma.
Eur J Haematol. A subset of t 11;14 lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease. Role and prognostic significance of the Ki index in non-Hodgkin's lymphoma. Immunohistochemical Ki67 labeling index has similar proliferation predictive power to various gene signatures in breast cancer.
Cancer Sci. Ki is a valuable prognostic predictor of lymphoma but its utility varies in lymphoma subtypes: evidence from a systematic meta-analysis. BMC Cancer. Impact of TP53 mutation and 17p deletion in mantle cell lymphoma. Mantle cell lymphoma is characterized by inactivation of the ATM gene. Clin Cancer Res. Understanding MYC-driven aggressive B-cell lymphomas: pathogenesis and classification. Dysregulation of BMI1 and microRNA collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma.
Int J Clin Exp Pathol. Toll-like receptors in the pathogenesis of human B cell malignancies. MicroRNAs in mantle cell lymphoma. MicroRNA signature obtained from the comparison of aggressive with indolent non-Hodgkin lymphomas: potential prognostic value in mantle-cell lymphoma. J Clin Oncol. Molecular pathogenesis of mantle cell lymphoma.
J Clin Invest. Nucl Med Commun. Outcome prediction of advanced mantle cell lymphoma by international prognostic index versus different mantle cell lymphoma indexes: one institution study. The impact of Cyclin D1 mRNA isoforms, morphology and p53 in mantle cell lymphoma: p53 alterations and blastoid morphology are strong predictors of a high proliferation index.
SOX11 overexpression is a specific marker for mantle cell lymphoma and correlates with t 11;14 translocation, CCND1 expression and an adverse prognosis. Elevated monoclonal and polyclonal serum immunoglobulin free light chain as prognostic factors in B- and T-cell non-Hodgkin lymphoma. Serum beta-2 microglobulin as a prognostic biomarker in patients with mantle cell lymphoma.
Hematol Oncol. Myc overexpression correlates with MYC amplification or translocation and is associated with poor prognosis in mantle cell lymphoma. TCL1 expression predicts overall survival in patients with mantle cell lymphoma. T-cell levels are prognostic in mantle cell lymphoma. Limited-stage mantle cell lymphoma: treatment outcomes at the Princess Margaret Hospital.
Effect of radiotherapy on the survival of patients with stage I and stage II mantle cell lymphoma: analysis of the Surveillance, Epidemiology and End Results database. Clin Lymphoma Myeloma Leuk. Follicular lymphoma, immunocytoma, and mantle cell lymphoma: randomized evaluation of curative radiotherapy in limited stage nodal disease. Ann Oncol. Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network.
Radiation therapy is an effective modality in the treatment of mantle cell lymphoma, even in heavily pretreated patients. Involved-field radiotherapy for patients with mantle cell lymphoma. J Med Imaging Radiat Oncol. Prolonged lymphocytopenia after bendamustine therapy in patients with relapsed or refractory indolent B-cell and mantle cell lymphoma.
Blood Cancer J. Rajguru S, Kahl BS. Emerging therapy for the treatment of mantle cell lymphoma. J Natl Compr Canc Netw. Management of mantle cell lymphoma in the elderly patient. Clin Interv Aging. Mature results of the M. D Anderson Cancer Center risk-adapted transplantation strategy in mantle cell lymphoma.
Autologous or reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chemotherapy-sensitive mantle-cell lymphoma: analysis of transplantation timing and modality. The hyper-CVAD-rituximab chemotherapy programme followed by high-dose busulfan, melphalan and autologous stem cell transplantation produces excellent event-free survival in patients with previously untreated mantle cell lymphoma.
Ann Hematol. Intensive chemotherapy and consolidation with high dose therapy and autologous stem cell transplant in patients with mantle cell lymphoma. Phase II study of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone immunochemotherapy followed by yttriumibritumomab tiuxetan in untreated mantle-cell lymphoma: Eastern Cooperative Oncology Group Study E Griffin MM, Morley N.
Rituximab in the treatment of non-Hodgkin's lymphoma - a critical evaluation of randomized controlled trials. Expert Opinion on Biological Therapy. Immunochemotherapy with rituximab and cyclophosphamide, doxorubicin, vincristine, and prednisone significantly improves response and time to treatment failure, but not long-term outcome in patients with previously untreated mantle cell lymphoma: results of a prospective randomized trial of the German Low Grade Lymphoma Study Group GLSG J Clin Oncol.
Gunnellini M, Falchi L. Adv Hematol. Clinical, metabolic and molecular responses after 4 courses of R-DHAP and after autologous stem cell transplantation for untreated mantle cell lymphoma patients included in the LyMa trial, a Lysa study. Combination of rituximab, bendamustine, and cytarabine for patients with mantle-cell non-Hodgkin lymphoma ineligible for intensive regimens or autologous transplantation. Prolonged immunochemotherapy with rituximab, cytarabine and fludarabine added to cyclophosphamide, doxorubicin, vincristine and prednisolone and followed by rituximab maintenance in untreated elderly patients with mantle cell lymphoma: a prospective study by the Finnish Lymphoma Group.
Rituximab, gemcitabine and oxaliplatin: an effective regimen in patients with refractory and relapsing mantle cell lymphoma. Phase II multicenter study of bendamustine plus rituximab in patients with relapsed indolent B-cell and mantle cell non-Hodgkin's lymphoma. Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphoma. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma.
Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma. Biol Blood Marrow Transplant. High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma. Mantle cell lymphoma cells express predominantly Cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.
Induction of apoptosis and down regulation of cell cycle proteins in mantle cell lymphoma by flavopiridol treatment. Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoproliferative disorders. Responses in mantle cell lymphoma cells to SNS depend on the biological context of each cell line. In vitro activity of cyclin-dependent kinase inhibitor CYC Seliciclib, R-roscovitine in mantle cell lymphomas.
P, a cyclin-dependent kinase inhibitor, modulates cell cycle and induces apoptosis in vitro and in vivo in mantle cell lymphoma cell lines. Mol Cancer. Initial testing stage 1 of the cyclin dependent kinase inhibitor SCH dinaciclib by the pediatric preclinical testing program.
Pediatr Blood Cancer. Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific CS BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma. Cancer Discov. Burger JA. Curr Hematol Malig Rep. Fowler N, Davis E. Targeting B-cell receptor signaling: changing the paradigm.
Inhibitors of BCR signalling interrupt the survival signal mediated by the micro-environment in mantle cell lymphoma. Int J Cancer. Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma. Exp Hematol Oncol. Targeting Bruton's tyrosine kinase in B cell malignancies. Characterization of ibrutinib-sensitive and -resistant mantle lymphoma cells. Mechanisms of ibrutinib resistance in chronic lymphocytic leukaemia and non-Hodgkin lymphoma. Smith SM. Targeting mTOR in mantle cell lymphoma: current and future directions.
Best Pract Res Clin Haematol. Mol Cancer Ther. Westin JR. CAL, a pdelta selective phosphatidylinositolkinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Cell Cycle. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. A phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory mantle cell lymphoma. The combination of bortezomib with enzastaurin or lenalidomide enhances cytotoxicity in follicular and mantle cell lymphoma cell lines.
Sarkar AK. MK disrupts cytoplasmic AKT-p21 complex in mantle cell lymphoma: Evidence of p21 coupled cell cycle arrest. American Association of Cancer Research meeting. Lipid raft-mediated Akt signaling as a therapeutic target in mantle cell lymphoma. Expression of heat-shock protein in non-Hodgkin's lymphomas. The heat shock protein 90 inhibitor AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting Cyclin D1, Akt, Bid and activating caspase 9.
Co-treatment with heat shock protein 90 inhibitor dimethylaminoethylaminodemethoxygeldanamycin DMAG and vorinostat: a highly active combination against human mantle cell lymphoma MCL cells. Cancer Biol Ther. Antiproliferative and proapoptotic activity of GUT mediated through potent inhibition of Hsp90 in mantle cell lymphoma.
Br J Cancer. Holkova B, Grant S. Proteasome inhibitors in mantle cell lymphoma. Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma. Evaluation of the proteasome inhibitor MLN in preclinical models of human cancer. In vitro and in vivo therapeutic efficacy of carfilzomib in mantle cell lymphoma: targeting the immunoproteasome. Cell Death and Disease. MDM2 small-molecule antagonist RG activates p53 signaling and regresses human tumors in preclinical cancer models.
Role of PARP inhibitors in cancer biology and therapy. Curr Med Chem. Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities.
Weniger MA, Wiestner A. Molecular targeted approaches in mantle cell lymphoma. Semin Hematol. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo : therapeutic implications.
Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines. Exp Hematol. Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma. Antiproliferative and proapoptotic effects of proteasome inhibitors and their combination with histone deacetylase inhibitors on leukemia cells.
Cardiovasc Hematol Disord Drug Targets. Romidepsin and belinostat synergize the antineoplastic effect of bortezomib in mantle cell lymphoma. Watanabe T. Investigational histone deacetylase inhibitors for non-Hodgkin lymphomas. Expert Opin Investig Drugs.
Mol Oncol. Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphoma. Phase I study of panobinostat plus everolimus in patients with relapsed or refractory lymphoma. Pim kinases in hematological malignancies: where are we now and where are we going? Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma.
Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma. J Biol Chem. The PIM kinases in hematological cancers. Expert Rev Hematol. Transcription and translation are primary targets of Pim kinase inhibitor SGI in mantle cell lymphoma. Bcl-2 inhibitors: small molecules with a big impact on cancer therapy. Cell Death Differ. Biological rational for sequential targeting of Bruton tyrosine kinase and Bcl-2 to overcome CDinduced ABT resistance in mantle cell lymphoma.
The BH3-mimetic GX synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Combination anti-CD74 milatuzumab and anti-CD20 rituximab monoclonal antibody therapy has in vitro and in vivo activity in mantle cell lymphoma. Safety and activity of the anti-CD79B antibody-drug conjugate polatuzumab vedotin in relapsed or refractory B-cell non-Hodgkin lymphoma and chronic lymphocytic leukaemia: a phase 1 study.
Potentiating the activity of rituximab against mantle cell lymphoma in mice by targeting interleukin-2 to the neovasculature. A novel vaccine for mantle cell lymphoma based on targeting Cyclin D1 to dendritic cells via CD Cyclin D as a therapeutic target in cancer. Benada J, Macurek L. Targeting the Checkpoint to Kill Cancer Cells. Furgason JM, Bahassi el M. Targeting DNA repair mechanisms in cancer. Pharmacol Ther. Identification of nuclear export inhibitors with potent anticancer activity in vivo.
TCL1A expression delineates biological and clinical variability in B-cell lymphoma. Mechanisms underlying nonsteroidal anti-inflammatory drug-induced p27 Kip1 expression. Mol Pharmacol. Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma. Liu Z, Davidson A. BAFF inhibition: a new class of drugs for the treatment of autoimmunity. Exp Cell Res. Yue P, Turkson J. Targeting STAT3 in cancer: how successful are we?
Biochem Biophys Res Commun. Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J Immunol. J Immunother Cancer. MDM2 antagonist Nutlin-3 enhances bortezomib-mediated mitochondrial apoptosis in TPmutated mantle cell lymphoma.
Cancer Lett. Therapeutic targeting of cancers with loss of PTEN function. Curr Drug Targets. Biochem Pharmacol. Five-gene model to predict survival in mantle-cell lymphoma using frozen or formalin-fixed, paraffin-embedded tissue. Repp a new prognostic marker in mantle cell lymphoma. Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol. Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.
Topoisomerase IIalpha expression in mantle cell lymphoma: a marker of cell proliferation and a prognostic factor for clinical outcome. Increased tumor cell proliferation in mantle cell lymphoma is associated with elevated insulin-like growth factor 2 mRNA-binding protein 3 expression. Semin Cancer Biol. Park S, Ko YH. CD expression may help in differential diagnosis between mantle cell lymphoma and B-cell chronic lymphocytic leukemia.
Clinicopathologic features of cases with mantle cell lymphoma. Cancer Biol Med. Interleukin 22 signaling promotes cell growth in mantle cell lymphoma. Transl Oncol. Drug discovery approaches to target Wnt signaling in cancer stem cells.
Biological and clinical significance of GSK-3beta in mantle cell lymphoma—an immunohistochemical study. Combination of rituximab with chlorambucil as first line treatment in patients with Mantle cell lymphoma: a highly effective regimen. Bortezomib plus CHOP-rituximab for previously untreated diffuse large B-cell lymphoma and mantle cell lymphoma.
A phase II clinical trial of intensive chemotherapy followed by consolidative stem cell transplant: long-term follow-up in newly diagnosed mantle cell lymphoma. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine.
Intensive chemotherapy and autologous stem-cell transplantation plus rituximab is superior to conventional chemotherapy for newly diagnosed advanced stage mantle-cell lymphoma: a matched pair analysis. Safety and efficacy of Temsirolimus in combination with Bendamustine and Rituximab in relapsed mantle cell and follicular lymphoma. Rituximab combined with DexaBEAM followed by high dose therapy as salvage therapy in patients with relapsed or refractory B-cell lymphoma: mature results of a phase II multicentre study.
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Characterization of Alisertib MLN , an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays. Everolimus for patients with mantle cell lymphoma refractory to or intolerant of bortezomib: multicentre, single-arm, phase 2 study. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase study. Drugs of the Future. J Antibiot Tokyo ; 64 — Rom J Oncol Hematol.
Norcantharidin, derivative of cantharidin, for cancer stem cells. Evid Based Complement Alternat Med. Pharmacol Rep. Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis. J Exp Ther Oncol. Nguyen TK, Grant S. Molecular Cancer Therapeutics. Cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains.
ACS Chemical Biology. Flavopiridol administered as a hour continuous infusion in chronic lymphocytic leukemia lacks clinical activity. Leukemia Research. Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. Perifosine, a novel alkylphospholipid, inhibits protein kinase B activation.
Perifosine as a potential novel anti-telomerase therapy. First-in-man clinical trial of the oral pan-AKT inhibitor MK in patients with advanced solid tumors. European journal of cancer. J Cancer Sci Ther. Ganetespib and HSP translating preclinical hypotheses into clinical promise. Phase I dose-escalation studies of SNX, an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumours. Eur J Cancer. Proteasome inhibition profoundly affects activated human B cells.
Ma L, Diao A. Marizomib, a potent second generation proteasome inhibitor from natural origin. Anticancer Agents Med Chem. The novel kinase inhibitor PRT Cerdulatinib demonstrates efficacy in models of autoimmunity and B-cell cancer. J Pharmacol Exp Ther. Phase II study of sorafenib in patients with relapsed or refractory lymphoma.
British journal of haematology. A phase I study of the histone deacetylase HDAC inhibitor entinostat, in combination with sorafenib in patients with advanced solid tumors. Investigational new drugs. A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas.
Drug Metab Lett. Molecular cancer therapeutics. Necessary for cell proliferation and RNA transcription. Induces cell cycle arrest, DNA repair, apoptosis. Homologous Recombination Repair and Cell Cycle regulation. CDK-mediated phosphorylation and removal of Cdc6. Cell cycle regulation, especially CDK-mediated phosphorylation and removal of Cdc6. Required for importing of proteins into nucleus as well as transporting RNA out of the nucleus. Controls DNA replication, causes B cell proliferation, regulates cell growth and apoptosis.
Coordinates response to DNA damage during cell cycle and regulates checkpoint in cell cycle. Enhances B-cell survival, regulates B-cell population. WP with vorinostat has been tested against MCL. Other STAT-3 inhibitors are also available. Controls DNA transcription, cytokine production, and cell survival. Cyclic Pifithrin-alpha hydrobromide and CP dihydrochloride stabilizes p Cellular Senescence and Cell Cycle Regulation. Regulator of entry into cell division, tumor suppressor. Transcriptional suppressor, suppresses genes related to differentiation, cell cycle, and apoptosis.
Anti-apoptotic protein regulates caspases and apoptosis, modulates inflammatory signaling and immunity. Tumor Necrosis factor receptor, Transduces apoptosis signals,. Spindle assembly factor, required for assembly of microtubules during apoptosis,. Cell cycle and IL immune response pathway.
Lenalidomide:immuno-modulatory agent, rituximab: anti-CD20 mAb. A assessed: , A2: assessed Chemoimmunotherapy followed by radioimmunotherapy. Intensive multiagent chemotherapeutic regimen. Acceptable, with no major differences between the two therapeutic groups.
Intensive chemotherapy A1 Vs. ASCT and rituximab A2. Treatment-related death occurred in five patients. Lenalidomide maintenance versus observation. MCL in Relapse and other B cell malignancies. Monoclonal antibody, immunomodulatory, immunosuppressant drug, Topoisomerase inhibitor, alkylating agent. Chlorambucil Leukeran Ambochlorin Amboclorin Linfozilin. Target: DNA synthesis. Induces cellular apoptosis: — Accumulation of cytosolic p Hematologic: Bone marrow suppression, anemia, leukopenia, neutropenia, thrombocytopenia, pancytopenia.
Gastrointestinal: Gastrointestinal disturbances Dermatologic: urticaria, angioneurotic edema, skin hypersensitivity. Other: pulmonary fibrosis, hepatotoxicity, fever, peripheral neuropathy, interstitial pneumonia, sterile cystitis, infertility, leukemia, secondary malignancies.
Lenalidomide Revlimid. Target: TNF-alpha inhibitor. T- cells activated via B7 pathway: — Tyrosine phosphorylation of CD Hematologic: Neutropenia, thrombocytopenia, anemia. Other: pneumonia, fatigue. Target: Bruton's tyrosine kinase inhibitor Mechanism of action: Inhibits BTK and activates pathways necessary for B-cell trafficking, chemotaxis, and adhesion.
Promotes cancer cell apoptosis, inhibits cell proliferation. Gastrointestinal: Diarrhea, nausea, peripheral edema, constipation, vomiting, loss of appetite. Other: fatigue, dyspnea, upper respiratory tract infection. Methotrexate TrexallRasuvoOtrexupMexate. Antineoplastic Agent, Antipsoriatic, Antirheumatic, Cytotoxic. Target: Dihydrofolate reductase inhibitor Mechanism of action: Inhibits folic acid reductase, hinders DNA synthesis and prevents cellular replication.
Hematologic: aplastic anemia, pancytopenia, leukopenia, neutropenia. Other: lymphadenopathy, drowsiness, blurred vision, cognitive dysfunction, moodiness, tinnitus, mucositis. Fludarabine FludaraOforta. Purine Nucleotides, Antimetabolites Antineoplastic Agents. Hematologic: neutropenia, thrombocytopenia, anemia, lymphocytopenia.
Gastrointestinal: nausea, vomiting.
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Liam Bailey - Blind Faith. Sub Focus Feat. Alpines - Tidal Wave. High Contrast - Remind Me. Nero - Must Be The Feeling. Plan B - End Credits. Delilah - Time. Nero - Doomsday. Wilkinson - Take You Higher. Jessie Ware - Midnight Goldie Remix. Ookay - Thief Flux Pavilion Remix. Bahamadia - New Forms. Nero - Promises Liam Bailey - Blind Faith Alpines - Tidal Wave High Contrast - Remind Me Nero - Must Be The Feeling Plan B - End Credits Delilah - Time Nero - Doomsday Wilkinson - Take You Higher Jessie Ware - Midnight Goldie Remix Ookay - Thief Flux Pavilion Remix Brutal Lex - American Psyho.
Bad Man - Sunny. Resynth - Chernobyl. J Cash - Ngorongoro. Paul Bexx. Total Destruction - Cataclysm. Napas - Back to Eclipse. Dj Emotion - Call in Hell. Zak Cator - Chapel. Followers 0. Prev 1 2 3 Next Page 1 of 3. Recommended Posts. Posted November 15, edited. BassBox Pro 6. Link to comment. Replies 35 Created 11 yr Last Reply May Top Posters In This Topic 3 2 3 4.
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